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- Title
Efficient Functionalization of Organosulfones via Photoredox Catalysis: Direct Incorporation of α -Carbonyl Alkyl Side Chains into α -Allyl- β -Ketosulfones.
- Authors
Huang, Hong-Li; Li, Shan; Lv, Yong-Zheng; Shi, Ya-Qian; Pang, Tian-Tian; Zhang, Ru-Fen; Huang, Wenjing; Yin, Jianhui; Gao, Fei
- Abstract
A novel and efficient method for functionalizing organosulfones has been established, utilizing a visible-light-driven intermolecular radical cascade cyclization of α-allyl-β-ketosulfones. This process employs fac-Ir(ppy)3 as the photoredox catalyst and α-carbonyl alkyl bromide as the oxidizing agent. Via this approach, the substrates experience intermolecular addition of α-carbonyl alkyl radicals to the alkene bonds, initiating a sequence of C-C bond formations that culminate in the production of organosulfone derivatives. Notably, this technique features gentle reaction conditions and an exceptional compatibility with a wide array of functional groups, making it a versatile and valuable addition to the field of organic synthesis.
- Subjects
CATALYSIS; ALKYL bromides; OXIDIZING agents; ORGANIC synthesis; RADICALS (Chemistry); ALKYL radicals
- Publication
Molecules, 2024, Vol 29, Issue 9, p1971
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules29091971