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- Title
New Synthetic Methodology for Drug-like Molecules.
- Authors
Barker, Graeme; Rapposelli, Simona
- Abstract
In this Special Issue, a diverse array of new methodologies for the synthesis of drug-like molecules is reported, highlighting the breadth of modern synthesis. Previous syntheses of these unusual structures relied on toxic Hg- or Sn-chemistry or expensive Indium reagents [[6], [8]], and this convenient new route will facilitate the investigation of their biological activities. Chem. 2006; 42: 36-41. 10.1134/S1070428006010064 3 Shults E.E., Velder J., Schmalz H.G., Chernov S.V., Rubalova T.V., Gatilov Y.V., Henze G., Tolstikov G.A., Prokop A. Gram-scale synthesis of pinusolide and evaluation of its antileukemic potential. 24471928 23 Miralinaghi P., Schmitt C., Hartmann R.W., Frotscher M., Engel M. 6-Hydroxybenzothiophene Ketones: Potent Inhibitors of 17 -Hydroxysteroid Dehydrogenase Type 1 (17 -HSD1) Owing to Favorable Molecule Geometry and Conformational Preorganization.
- Subjects
ENANTIOMERS; MOLECULES; CARBAMATE derivatives; ELECTROPHILIC substitution reactions; NOBEL Prize in Chemistry; URACIL derivatives
- Publication
Molecules, 2023, Vol 28, Issue 15, p5632
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules28155632