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- Title
Comparison of time-action profiles of insulin Glargine and NPH insulin in normal and diabetic dogs.
- Authors
A. Mori; T. Sako; P. Lee; T. Motoike; K. Iwase; Y. Kanaya; H. Fukuta; H. Mizutani; T. Arai
- Abstract
Abstract Intermediate insulin injections are commonly used for glycemic control in insulin dependent diabetic dogs acting as a replacement for natural insulin. Neutral Protamin Hagedorn (NPH) insulin and insulin glargine are two types of injectable insulin preparations commonly used in humans. In our study, we investigated the time-action profiles of both aforementioned insulin preparations in normal dogs in order to determine whether co-administration of NPH and glargine would be of benefit to insulin dependent diabetic dogs as it is for humans suffering from insulin dependent diabetes. Time-action profiles of NPH insulin and insulin glargine in normal dogs demonstrated a clear difference between both insulin preparations confirming that NPH insulin is an intermediate-acting preparation whereas insulin glargine is a long-lasting preparation. In addition, co-administration of NPH insulin and insulin glargine resulted in tight glycemic control as compared to NPH insulin alone in insulin dependent diabetic dogs. However, co-administration result in hypoglycemia at the dosages tested.
- Subjects
INSULIN derivatives; INJECTIONS; COMPARATIVE studies; DOG physiology; HYPOGLYCEMIA; TREATMENT of diabetes
- Publication
Veterinary Research Communications, 2008, Vol 32, Issue 7, p563
- ISSN
0165-7380
- Publication type
Article
- DOI
10.1007/s11259-008-9059-5