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- Title
Neutrophils, but Not Monocytes or Microglia, Degraded lnterleukin-1βin vitro.
- Authors
Fincher IV, Edgar F.; Pabst, Michael J.; Krueger, James M.
- Abstract
Interleukin-1β(IL-1β) is a key regulatory component of host defense systems, and it is involved in physiological regulation including several central nervous system functions like fever and sleep. Nevertheless, little is known about how IL-1βis degraded. Based on their protease secreting capabilities, the ability of microglia, monocytes, and neutrophils to degrade IL-1βwas studied. Neutrophil cultures degraded IL-1β, whereas microglia and monocyte cultures did not. The degradation if IL-1βby neutrophils may constitute a downregulation mechanism for IL-1β. Copyright © 1996 S. Karger AG, Basel
- Publication
Neuroimmunomodulation, 1996, Vol 3, Issue 2/3, p82
- ISSN
1021-7401
- Publication type
Article
- DOI
10.1159/000097231