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- Title
EP384 THE ANTI-BIOFILM ACTIVITY OF A WOUND DEBRIDEMENT GEL VERSUS A VARIETY OF ANTIMICROBIAL SOAKS AND MECHANICAL DEBRIDEMENT DEVICES USING A STRINGENT IN VITRO BIOFILM MODEL.
- Authors
Metcalf, Dan; Meredith, Kate
- Abstract
Introduction: The recognition of biofilm as a barrier to wound healing means that antimicrobial cleansers, soaks and debridement products should effectively remove biofilm as part of wound hygiene. Aim: To compare the anti-biofilm efficacy of a wound debridement gel (WDG), with commonly used antimicrobial solution soaks and mechanical debridement devices. Method: Test products (and controls) were assessed within a validated gauze biofilm model against Methicillin-resistant Staphylococcus aureus (MRSA) and multi-drug resistant Pseudomonas aeruginosa (RPA). Biofilms were cultured on gauze for 48 hours in nutritious broth and foetal bovine serum mixture and then treated with test products: WDG; 4 different antimicrobial solution soaks; and physical removal with 3 different pads/wipes. Enumeration of surviving biofilm bacteria was performed in triplicate for each test product and cell counts compared using 2-tailed independent T-tests. Results: The anti-biofilm activity of WDG was demonstrated to be rapid with >6 log10 reductions in MRSA and RPA biofilm after 2x2-minute applications. When compared with a range of antimicrobial solution soaks and mechanical debridement devices, WDG demonstrated markedly greater reductions in biofilm cell counts of MRSA and RPA than observed for any other method tested. Conclusion: WDG demonstrated a markedly greater kill of biofilm than other antimicrobial solution soaks and mechanical debridement devices tested using a stringent in vitro biofilm model. It is unclear how these in vitro tests translate to clinical use, however, recent clinical data has also shown the effectiveness of this wound debridement gel.
- Subjects
ITALY; BACTERIAL disease treatment; BIOLOGICAL models; DEBRIDEMENT; ANTI-infective agents; BIOFILMS; CONFERENCES &; conventions; TREATMENT effectiveness; SURGICAL dressings; BANDAGES &; bandaging; WOUND care
- Publication
Journal of Wound Management, 2023, Vol 24, Issue 2, p245
- ISSN
2788-5771
- Publication type
Article