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- Title
CIRCULATORY EFFECTS OF THE VENOM OF THE INDIAN COBRA (NAIA NAIA) IN CATS.
- Authors
Feldberg, W.; Kellaway, C. H.
- Abstract
1. In cats, under dial anaesthesia, intravenous injection of cobra venom (0-25 -- 0-5 mg. per kg.) causes an immediate steep fall of systemic pressure. Death may occur within a few minutes. If recovery of the blood pressure takes place there is a secondary gradual fall, resulting eventually in death. In cats, under chloralose. larger doses of venom are necessary to produce these effects. 2. The immediate steep fall of systemic pressure is accounted for by obstruction in the pulmonary circulation; peripheral vasodilatation, constriction of the liver vessels and heart failure do not contribute to it. The steep fall in systemic pressure is accompanied or preceded by a rise of pressure in the pulmonary artery and a fall of pressure in the pulmonary vein. Venom injected into the femoral artery causes immediate vasoconstriction in the hind limb. 3. The late gradual fall of systemic pressure is accounted for by fluid loss from circulation, probably associated with peripheral vasodilatation, haemorrhagic oedema of the lungs and, in some cases, failure of the heart action.
- Subjects
COBRA venom factor; CATS as laboratory animals; BLOOD pressure; PULMONARY circulation; VASODILATION
- Publication
Australian Journal of Experimental Biology & Medical Science, 1937, Vol 15, Issue 3, p159
- ISSN
0004-945X
- Publication type
Article
- DOI
10.1038/icb.1937.16