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- Title
Diagnostika autoimunitních puchýřnatých onemocnění.
- Authors
Jedličková, Hana
- Abstract
Autoimmune blistering diseases are rare organ-specific autoimmune diseases characterized by autoantibodies against desmosomal and hemidesmosomal adhesive proteins of epidermis. They can be divided into two main groups – pemphigus group with intraepidermal blisters and pemphigoid group with subepidermal blisters. Correct diagnosis of the subtypes is based on a complex of clinical observation, histopatological and immunofluorescence examinations, detection of circulating autoantibodies by indirect immunofluorescence, enzyme-linked immunosorbent assay (ELISA) and immunoblotting, thus allowing the precise diagnosis and the choice of appropriate therapy.
- Subjects
BULLOUS pemphigoid; ENZYME-linked immunosorbent assay; AUTOIMMUNE diseases; AUTOANTIBODIES; PEMPHIGUS; IMMUNOFLUORESCENCE
- Publication
Dermatologie Pro Praxi, 2022, Vol 16, Issue 4, p199
- ISSN
1802-2960
- Publication type
Article
- DOI
10.36290/der.2022.040