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- Title
Neurological Manifestations and Complications of the Central Nervous System as Risk Factors and Predictors of Mortality in Patients Hospitalized with COVID-19: A Cohort Study.
- Authors
Corona-Nakamura, Ana Luisa; Arias-Merino, Martha Judith; Morfín-Otero, Rayo; Rodriguez-Zavala, Guillermo; León-Gil, Alfredo; Camarillo-Escalera, Juan Ramsés; Reyes-Cortés, Idarmis Brisseida; Valdovinos-Ortega, María Gisela; Nava-Escobar, Erick René; Villaseñor-Corona, Ana María de la Paz; Mireles-Ramírez, Mario Alberto; Cisneros-Aréchiga, Aldo Guadalupe; Torre, Ofelia Padilla-De la; Pérez-Gómez, Héctor Raúl; Rodríguez-Noriega, Eduardo
- Abstract
The aim of this study was to analyze the risk factors and predictors of mortality in a retrospective cohort of patients with coronavirus disease (COVID-19) who presented central nervous system (CNS) manifestations and complications when admitted to hospital. Patients hospitalized from 2020 to 2022 were selected. Demographic variables; history of neurological, cardiological and pulmonary manifestations; comorbidities; prognostic severity scales; and laboratory tests were included. Univariate and adjusted analyses were performed to determine risk factors and predictors of mortality. A forest plot diagram was used to show the strength of the associated risk factors. The cohort included 991 patients; at admission, 463 patients presented CNS damage and of these, 96 hospitalized patients presented de novo CNS manifestations and complications. We estimate a general mortality of 43.7% (433/991) and 77.1% (74/96), for hospitalized patients with de novo CNS manifestations and complications, respectively. The following were identified as risks for the development of hospital CNS manifestations and complications when in hospital: an age of ≥64 years, a history of neurological disease, de novo deep vein thrombosis, D-dimer ≥ 1000 ng/dL, a SOFA ≥ 5, and a CORADS 6. In a multivariable analysis, the mortality predictors were an age of ≥64 years, a SOFA ≥ 5, D-dimer ≥ 1000 ng/mL and hospital CNS manifestations and complications when admitted to hospital. Old age, being hospitalized in critical condition, and having CNS manifestations and complications in hospital are predictors of mortality in hospitalized patients with COVID-19.
- Subjects
COVID-19; MORTALITY risk factors; CENTRAL nervous system; NEUROLOGIC manifestations of general diseases; VENOUS thrombosis
- Publication
Journal of Clinical Medicine, 2023, Vol 12, Issue 12, p4065
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm12124065