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- Title
Cognitive and Adaptive Effects of Early Growth Hormone Treatment in Prader–Willi Syndrome Patients: A Cohort Study.
- Authors
Ayet-Roger, Aitana; Joga-Elvira, Lorena; Caixàs, Assumpta; Corripio, Raquel
- Abstract
Background: Prader–Willi Syndrome (PWS) is a genetically based neurodevelopmental disease characterized by obesity, hyperphagia, and mild to moderate intellectual disability. Treatment with growth hormone (GH) could provide cognitive benefits. The objective of the present study was to compare the cognitive and adaptive performance of 31 patients with genetically confirmed PWS grouped in two cohorts, one treated with GH before 2 years old (Group 1) and the other receiving the treatment later (Group 2). Method: We compared two variables necessary to diagnose intellectual disability: intellectual performance, using the Weschler scales, and adaptive behavior, using the DABS scale. The scores were analyzed by means of non-parametric statistical tests. Results: Group 1 (n = 10) obtained higher and statistically significant scores in Total Intelligence Quotient (TIQ), General Ability Index (GAI), and General Adaptive Behavior (GAB), implying better cognitive and adaptive performance compared to Group 2. Conclusions: Treatment with GH should be administered in the early stage of development (before 2 years old) to obtain greater benefits at the cognitive and adaptive levels.
- Subjects
PRADER-Willi syndrome; SOMATOTROPIN; COHORT analysis; INTELLIGENCE levels; INTELLECTUAL disabilities
- Publication
Journal of Clinical Medicine, 2022, Vol 11, Issue 6, p1592
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm11061592