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- Title
Arrhythmias in COVID-19/SARS-CoV-2 Pneumonia Infection: Prevalence and Implication for Outcomes.
- Authors
Denegri, Andrea; Sola, Matteo; Morelli, Marianna; Farioli, Francesco; Alberto, Tosetti; D'Arienzo, Matteo; Savorani, Fulvio; Pezzuto, Giuseppe Stefano; Boriani, Giuseppe; Szarpak, Lukasz; Magnani, Giulia
- Abstract
Arrhythmias (ARs) are potential cardiovascular complication of COVID-19 but may also have a prognostic role. The aim of this study was to explore the prevalence and impact of cardiac ARs in hospitalized COVID-19 patients. All-comer patients admitted to the emergency department of Modena University Hospital from 16 March to 31 December 2020 and diagnosed with COVID-19 pneumonia infection were included in the study. The primary endpoint was 30-day mortality. Out of 902 patients, 637 (70.6%) presented a baseline 12-lead ECG registration; of these, 122 (19.2%) were diagnosed with ARs. Atrial fibrillation (AF, 40.2%) was the most frequent AR detected. The primary endpoint (30-day mortality) occurred in 33.6% (p < 0.001). AR-patients presented an almost 3-fold risk of mortality compared to non-AR-patients at 30d (Adj. OR = 2.8, 95%CI: 1.8–4.3, p < 0.001). After adjustment for significant baseline characteristics selected by a stepwise backward selection, AR-patients remained at increased risk of mortality (Adj. HR = 2.0, 95%CI: 1.9–2.3, p < 0.001). Sub-group analysis revealed that among ARs patients, those with AF at admission presented the highest risk of 30-day mortality (Adj. HR = 3.1, 95%CI: 2.0–4.9, p < 0.001). In conclusion, ARs are a quite common manifestation in COVID-19 patients, who are burdened by even worse prognosis. AR patients with AF presented the highest risk of mortality; thus, these patients may benefit from a more aggressive secondary preventive therapy and a closer follow up.
- Subjects
COVID-19; ATRIAL fibrillation; CARDIOLOGICAL manifestations of general diseases; ARRHYTHMIA; PNEUMONIA; HOSPITAL patients
- Publication
Journal of Clinical Medicine, 2022, Vol 11, Issue 5, p1463
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm11051463