We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Rationale, Design, and Feasibility of a Prospective Multicenter Registry Study of Anthracycline-Induced Cardiotoxicity (AIC Registry).
- Authors
Inoue, Keiko; Iida, Noriko; Tajiri, Kazuko; Bando, Hiroko; Chiba, Shigeru; Tasaka, Nobutaka; Nagashio, Kenji; Sasamura, Rumi; Naito, Hiroyuki; Murata, Momoko; Li, Siqi; Ishizu, Tomoko; Nakazawa, Yoko; Sekine, Ikuo; Ieda, Masaki; Howell, Doris
- Abstract
As the number of cancer survivors increases, cardiac management in anthracycline-treated patients has become more important. We planned to conduct a prospective multicenter registry study for comprehensive echocardiographic and biomarker data collection and an evaluation of the current practice in terms of diagnosis and management of anthracycline-induced cardiotoxicity (AIC registry). To examine the feasibility of this registry study, we analyzed the 1-year follow-up data of 97 patients registered during the first year of this registry. The AIC registry was launched in July 2016. Data on echocardiographic parameters (e.g., two-and three-dimensional [(2- and 3-D) left ventricular ejection fraction (LVEF) and global longitudinal strain (GLS)) and biomarkers (e.g., troponin T and brain natriuretic peptide) were collected before anthracycline treatment, every 3 months during the first year after starting anthracycline, and every 6 months during the second year. Eighty-three patients (86%) completed a 1-year follow-up. The measurable rates of 2D LVEF, 3D LVEF, and GLS on each visit were nearly optimal (100%, 86–93%, and 84–94%, respectively). During the 1-year follow-up, 5 patients (6.0%) developed cardiotoxicity (a reduction in LVEF ≥ 10 percentage points from baseline and <55%). The AIC registry study is feasible and will be the first study to collect sizable echocardiographic and biomarker data on cardiotoxicity in Japanese patients treated with anthracycline in a real-world setting.
- Subjects
VENTRICULAR ejection fraction; CARDIOTOXICITY; BRAIN natriuretic factor; JAPANESE people
- Publication
Journal of Clinical Medicine, 2021, Vol 10, Issue 7, p1370
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm10071370