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- Title
Prediction Models for the 5- and 10-Year Incidence of Home Morning Hypertension: The Ohasama Study.
- Authors
Satoh, Michihiro; Metoki, Hirohito; Asayama, Kei; Kikuya, Masahiro; Murakami, Takahisa; Tatsumi, Yukako; Hara, Azusa; Tsubota-Utsugi, Megumi; Hirose, Takuo; Inoue, Ryusuke; Nomura, Kyoko; Hozawa, Atsushi; Imai, Yutaka; Ohkubo, Takayoshi
- Abstract
Background We aimed to develop risk prediction models for new-onset home morning hypertension. Methods We followed up 978 participants without home hypertension in the general population of Ohasama, Japan (men: 30.1%, age: 53.3 years). The participants were divided into derivation (n = 489) and validation (n = 489) cohorts by their residential area. The C -statistics and calibration plots were assessed after the 5- or 10-year follow-up. Results In the derivation cohort, sex, age, body mass index, smoking, office systolic blood pressure (SBP), and home SBP at baseline were selected as significant risk factors for new-onset home hypertension (≥135/85 mm Hg or the initiation of antihypertensive treatment) using the Cox model. In the validation cohort, Harrell's C -statistic for the 5-/10-year home hypertension was 0.7637 (0.7195–0.8100)/0.7308 (0.6932–0.7677), when we used the full model, which included the significant risk factors in the derivation cohort. The calibration test revealed good concordance between the observed and predicted 5-/10-year home hypertension probabilities (P ≥ 0.19); the regression slope of the observed probability on the predicted probability was 1.10/1.02, and the intercept was −0.04/0.06, respectively. A model without home SBP was also developed; for the 10-year home hypertension risk, the calibration test revealed a good concordance (P = 0.19) but Harrell's C -statistic was 0.6689 (0.6266–0.7067). Conclusions The full model revealed good ability to predict the 5- and 10-year home morning hypertension risk. Although the model without home SBP is acceptable, the low C -statistic implies that home BP should be measured to predict home morning hypertension precisely.
- Subjects
JAPAN; SYSTOLIC blood pressure; PREDICTION models; BODY mass index; HYPERTENSION
- Publication
American Journal of Hypertension, 2022, Vol 35, Issue 4, p328
- ISSN
0895-7061
- Publication type
Article
- DOI
10.1093/ajh/hpab177