We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Anti-mitotic Activity of Methanolic Extract of Thevetia peruviana fruits.
- Authors
Kanthal, Lakshmi Kanta; Pattanayak, Suman; Roy, Susmita; Panda, Pritish Kumar; Ari, Rahul; Mondal, Sanchayan; Midya, Saikat; Golui, Argho
- Abstract
Thevetia peruviana plant, a member of the Apocynaceae family, has a long history in traditional medicine for treating various ailments such as amenorrhea, malaria, jaundice, hemorrhoids, constipation, headaches, and skin issues. It contains significant amounts of cardiac glycosides in both its roots and seeds, which are known for their cytotoxic effects similar to digoxin. Given its potential toxicity and widespread use, current research is focused on assessing the antimitotic properties of the methanolic extract derived from the fruits of Thevetia peruviana. In the pursuit of potential pharmaceutical findings from plants, the antimitotic properties of the extracts were investigated through the Allium cepa assay. The findings indicated a noteworthy decrease in the mitotic index of root tips compared to the control, with the degree of mitotic suppression escalating alongside the concentration of the extracts. Therefore, the study suggests that the methanol extract derived from T. peruviana fruit has notable inhibitory and mitodepressive impacts on cell division in Allium cepa L. meristems.
- Subjects
ONIONS; CARDIAC glycosides; HISTORY of medicine; FRUIT; CELL division
- Publication
Journal of Drug Delivery & Therapeutics, 2024, Vol 14, Issue 5, p44
- ISSN
2250-1177
- Publication type
Article
- DOI
10.22270/jddt.v14i5.6531