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- Title
Phenylhydrazine haematotoxicity.
- Authors
Berger, Josef
- Abstract
Phenylhydrazine (PHZ) and its derivatives were first given a medical application at the end of the 19th century but with with very little benefit. However, this compound seems to be very useful in models studying mechanisms of haemolytic anaemia. Phenylhydrazine induces a reactive oxygen species formation, peroxidation of lipids and oxidative degradation of spectrin in the membrane skeleton. PHZinduced haemolytic injury seems to be derived from oxidative alternations to red blood cell proteins. This compound can modulate immune reactions.
- Subjects
PHENYLHYDRAZINE; HEMATOLOGY; HEMOLYTIC plaque technique; ANEMIA; ERYTHROCYTES
- Publication
Journal of Applied Biomedicine, 2007, Vol 5, Issue 3, p125
- ISSN
1214-021X
- Publication type
Article
- DOI
10.32725/jab.2007.017