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- Title
Chronic Kidney Disease Associated with Ischemic Heart Disease: To What Extent Do Biomarkers Help?
- Authors
Cepoi, Maria-Ruxandra; Duca, Stefania Teodora; Chetran, Adriana; Costache, Alexandru Dan; Spiridon, Marilena Renata; Afrăsânie, Irina; Leancă, Sabina Andreea; Dmour, Bianca-Ana; Matei, Iulian Theodor; Miftode, Radu Stefan; Miftode, Larisa; Prepeliuc, Cristian Sorin; Haba, Mihai Ștefan Cristian; Bădescu, Minerva Codruța; Costache, Irina Iuliana
- Abstract
Chronic kidney disease represents a complex and multifaceted pathology characterized by the presence of structural or functional renal anomalies associated with a persistent reduction in renal function. As the disease progresses, complications arise due to the chronic inflammatory syndrome, hydro-electrolytic disorders, and toxicity secondary to the uremic environment. Cardiovascular complications are the leading cause of death for these patients. Ischemic cardiac pathology can be both a consequence and complication of chronic kidney disease, highlighting the need to identify specific cardiorenal dysfunction biomarkers targeting pathophysiological mechanisms common to both conditions. This identification is crucial for establishing accurate diagnoses, prognoses, and risk stratifications for patients. This work is intended to elucidate the intricate relationship between chronic kidney disease and ischemic heart disease and to investigate the roles of cardiorenal biomarkers, including cardiac troponin, natriuretic peptides, galectin-3, copeptin, fibroblast growth factor 23 and its co-receptor Klotho, soluble suppression of tumorigenicity 2, and plasma growth differentiation factor 15.
- Subjects
MYOCARDIAL ischemia; CORONARY disease; COPEPTINS; CHRONIC kidney failure; GROWTH differentiation factors; FIBROBLAST growth factors; BRAIN natriuretic factor
- Publication
Life (2075-1729), 2024, Vol 14, Issue 1, p34
- ISSN
2075-1729
- Publication type
Article
- DOI
10.3390/life14010034