We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Interfering with reconsolidation by rimonabant results in blockade of heroin-associated memory.
- Authors
Jiang Lin; Yilin Peng; Jinlong Zhang; Junzhe Cheng; Qianqian Chen; Binbin Wang; Yuhang Liu; Shuliang Niu; Jie Yan
- Abstract
Drug-associated pathological memory remains a critical factor contributing to the persistence of substance use disorder. Pharmacological amnestic manipulation to interfere with drug memory reconsolidation has shown promise for the prevention of relapse. In a rat heroin self-administration model, we examined the impact of rimonabant, a selective cannabinoid receptor indirect agonist, on the reconsolidation process of heroin-associated memory. The study showed that immediately administering rimonabant after conditioned stimuli (CS) exposure reduced the cue- and herion + cue-induced heroin-seeking behavior. The inhibitory effects lasted for a minimum of 28 days. The effect of Rimonabant on reduced drug-seeking was not shown when treated without CS exposure or 6 hours after CS exposure. These results demonstrate a disruptive role of rimonabant on the reconsolidation of heroin-associated memory and the therapeutic potential in relapse control concerning substance use disorder.
- Subjects
HEROIN; RIMONABANT; CANNABINOID receptors; MEMORY; BLOCKADE; SUBSTANCE abuse
- Publication
Frontiers in Pharmacology, 2024, p01
- ISSN
1663-9812
- Publication type
Article
- DOI
10.3389/fphar.2024.1361838