We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Maternal insulin resistance and maternal β‐cell function during pregnancy for offspring overweight before 2 years of age among women with gestational diabetes.
- Authors
Gao, Ming; Wang, Hui; Li, Weiqin; Wang, Leishen; Li, Ninghua; Qiao, Yijuan; Zhang, Tao; Li, Jing; Yu, Zhijie; Hu, Gang; Leng, Junhong; Yang, Xilin
- Abstract
Summary: Objective: To explore associations of maternal insulin resistance and β‐cell dysfunction with offspring overweight before 24 months of age among children of Chinese women with gestational diabetes mellitus (GDM). Methods: Offspring of women with GDM (n = 901) who were enrolled in a lifestyle trial during pregnancy were followed up to 24 months of age in Tianjin, China. Restricted cubic spline analysis was performed to examine full‐range associations of maternal homeostatic model assessment of insulin resistance (HOMA‐IR) and β‐cell function (HOMA‐%β) with childhood overweight. Logistic regression was performed to obtain the odds ratios (ORs) and 95% confidence interval (CI) of maternal high HOMA‐IR and low HOMA‐%β at diagnosis of GDM for offspring overweight within 12 months of age and at 13–24 months of age. Results: Maternal high HOMA‐IR was associated with an increased risk of offspring being overweight within 12 months of age and at 13–24 months of age (OR: 1.71, 95%CI: 1.12–2.62 & 1.89, 1.13–3.17, respectively). Maternal low HOMA‐%β was associated with an increased risk of offspring being overweight at 13–24 months of age (1.64, 1.05–2.55). Conclusions: Both maternal increased insulin resistance and decreased β‐cell function at diagnosis of GDM were associated with elevated risk of offspring overweight in early childhood among Chinese women with GDM.
- Subjects
CHINA; RISK of childhood obesity; CONFIDENCE intervals; PREGNANT women; RISK assessment; RESEARCH funding; DESCRIPTIVE statistics; GESTATIONAL diabetes; LOGISTIC regression analysis; ODDS ratio; INSULIN resistance; PANCREATIC beta cells; PREGNANCY
- Publication
Pediatric Obesity, 2023, Vol 18, Issue 3, p1
- ISSN
2047-6302
- Publication type
Article
- DOI
10.1111/ijpo.12995