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- Title
EXPERIMENTAL GLOMERULONEPHRITIS IN THE MOUSE.
- Authors
Avasthi, P. S.; Avasthi, Pushpa; Tokuda, Sei; Anderson, R. E.; Williams Jr., R. C.
- Abstract
Mice immunized with dog glomerular basement membrane in Fruend's complete adjuvant uniformly developed severe renal lesions. A prominent event in many animals appeared to be mononuclear cell accumulation around small renal blood vessels. Glomerular lesions characterized by hypercellularity, thickening of basement membrane, necrosis, and well marked crescent formation were noted. Immunofluoresecnt and antibody elution studies from the kidneys of animals immunized with dog GBM demonstrated the presence of specific anti-GBM antibody which could be detected in mouse glomeruli 4 weeks after initial immunization.
- Subjects
PRECANCEROUS conditions; CELLS; IMMUNOGLOBULINS; KIDNEYS; CANCER; BIOLOGY
- Publication
Clinical & Experimental Immunology, 1971, Vol 9, Issue 5, p667
- ISSN
0009-9104
- Publication type
Article