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- Title
False Positive Radioiodinated Metaiodobenzylguanidine (<sup>123</sup>I-MIBG) Uptake in Undifferentiated Adrenal Malignant Tumor.
- Authors
Jung, Hee Soo; Moon, Seok Jun; Kim, Yun Mi; Kang, Hye Rim; Lee, Seok Mo; Jung, Soo Jin; Choi, Seok Jin; Kim, Tae Kyoon; Kwon, Min Jeong; Park, Jeong Hyun; Lee, Soon Hee
- Abstract
123I-Metaiodobenzylguanidine (123I-MIBG) scintigraphy is a widely used functional imaging tool with a high degree of sensitivity and specificity in diagnosis of pheochromocytoma. However, rare cases of false positive reactions have been reported. A 67-year-old male patient was admitted with epigastric pain. Abdominal computed tomography (CT) revealed a heterogeneous left adrenal mass 6 cm in diameter; following hormone testing, 123I-MIBG scintigraphy was performed to determine the presence of pheochromocytoma, which confirmed eccentric uptake by a large left adrenal gland mass. Chest CT and PET-CT confirmed metastatic lymphadenopathy; therefore, endobronchial ultrasound transbronchial needle aspiration was performed. Metastatic carcinoma of unknown origin was suspected from a lymph node biopsy, and surgical resection was performed for definitive diagnosis and correction of excess hormonal secretion. A final diagnosis of undifferentiated adrenal malignant tumor was rendered, instead of histologically malignant pheochromocytoma, despite the uptake of 123I-MIBG demonstrated by scintigraphy.
- Subjects
GUANIDINES; ADRENAL tumors; RADIONUCLIDE imaging; PHEOCHROMOCYTOMA; ABDOMINAL radiography; LYMPHADENITIS; METASTASIS
- Publication
Case Reports in Oncological Medicine, 2015, Vol 2015, p1
- ISSN
2090-6706
- Publication type
Article
- DOI
10.1155/2015/164280