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- Title
Locus specific endogenous retroviral expression associated with Alzheimer's disease.
- Authors
Dawson, Tyson; Rentia, Uzma; Sanford, Jessie; Cruchaga, Carlos; Kauwe, John S. K.; Crandall, Keith A.
- Abstract
Introduction: Human endogenous retroviruses (HERVs) are transcriptionally-active remnants of ancient retroviral infections that may play a role in Alzheimer's disease. Methods: We combined two, publicly available RNA-Seq datasets with a third, novel dataset for a total cohort of 103 patients with Alzheimer's disease and 45 healthy controls. We use telescope to perform HERV quantification for these samples and simultaneously perform gene expression analysis. Results: We identify differentially expressed genes and differentially expressed HERVs in Alzheimer's disease patients. Differentially expressed HERVs are scattered throughout the genome; many of them are members of the HERVK superfamily. A number of HERVs are correlated with the expression of dysregulated genes in Alzheimer's and are physically proximal to genes which drive disease pathways. Discussion: Dysregulated expression of ancient retroviral insertions in the human genome are present in Alzheimer's disease and show localization patterns that may explain how these elements drive pathogenic gene expression.
- Subjects
RNA analysis; ALZHEIMER'S disease; RETROVIRUS diseases; GENE expression; CELLULAR signal transduction; RESEARCH funding; DESCRIPTIVE statistics; DATA analysis software; DISEASE complications
- Publication
Frontiers in Aging Neuroscience, 2023, p1
- ISSN
1663-4365
- Publication type
Article
- DOI
10.3389/fnagi.2023.1186470