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- Title
CARDIOPROTECTIVE EFFECT OF NELUMBO NUCIFERA LINN., LEAF EXTRACT ON ALUMINIUM CHLORIDE INDUCED TOXICITY IN ALBINO RATS.
- Authors
Sathiya, G.; Prasanna, G.
- Abstract
Heavy metals are important toxicants known to exerts adverse effect in human and animals due to exposure and accumulation in the body. This has a great concern both at personal and public health level. The adverse effect of the absorbed and accumulation of heavy metals include neurological, cardiological and haematological system. In order to determine the effect to aluminium on heart tissues of experimental animals, male albino rats (b/w 150-175gm) were taken and divided in to four groups (n=6), Group I-normal control rats, Group - II - Aluminium Chloride treated rats (35mg/kg of bw), Group III- Aluminium Chloride and Nelumbo Nucifera treated rats (200mg/kg of bw), Group IV - Plant extract alone treated rats. The dosage were given over a period of 21 days were investigated for biochemical findings, which showed that the elevation of Protein, Cholesterol, Triglycerides, AST, ALT and reduction of enzymatic antioxidant Catalase and Glutathoine peroxidase on aluminium chloride treated groups and these levels retrieved to normal when treated with plant extract. The result suggested that the extract of Nelumbo Nucifera possesses potential Cardioprotective activity may be due to the presence of Phytochemicals such as Alkaloids, flavonod and Phenols etc.
- Subjects
ALUMINUM chloride; PLANT extracts; LABORATORY rats; PUBLIC health; EAST Indian lotus; HEAVY metals
- Publication
International Journal of Pharmacology & Biological Sciences, 2011, Vol 5, Issue 3, p61
- ISSN
0973-6808
- Publication type
Article