We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Bioresorbable Stent in Anterior Cruciate Ligament Reconstruction.
- Authors
Ficek, Krzysztof; Rajca, Jolanta; Stolarz, Mateusz; Stodolak-Zych, Ewa; Wieczorek, Jarosław; Muzalewska, Małgorzata; Wyleżoł, Marek; Wróbel, Zygmunt; Binkowski, Marcin; Błażewicz, Stanisław
- Abstract
The exact causes of failure of anterior cruciate ligament (ACL) reconstruction are still unknown. A key to successful ACL reconstruction is the prevention of bone tunnel enlargement (BTE). In this study, a new strategy to improve the outcome of ACL reconstruction was analyzed using a bioresorbable polylactide (PLA) stent as a catalyst for the healing process. The study included 24 sheep with 12 months of age. The animals were randomized to the PLA group (n = 16) and control group (n = 8), subjected to the ACL reconstruction with and without the implantation of the PLA tube, respectively. The sheep were sacrificed 6 or 12 weeks post-procedure, and their knee joints were evaluated by X-ray microcomputed tomography with a 50 μm resolution. While the analysis of tibial and femoral tunnel diameters and volumes demonstrated the presence of BTE in both groups, the enlargement was less evident in the PLA group. Also, the microstructural parameters of the bone adjacent to the tunnels tended to be better in the PLA group. This suggested that the implantation of a bioresorbable PLA tube might facilitate osteointegration of the tendon graft after the ACL reconstruction. The beneficial effects of the stent were likely associated with osteogenic and osteoconductive properties of polylactide.
- Subjects
ANTERIOR cruciate ligament surgery; ANTERIOR cruciate ligament; POLYLACTIC acid; KNEE
- Publication
Polymers (20734360), 2019, Vol 11, Issue 12, p1961
- ISSN
2073-4360
- Publication type
Article
- DOI
10.3390/polym11121961