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- Title
Dengue Fever Surveillance in Mato Grosso do Sul: Insights from Genomic Analysis and Implications for Public Health Strategies.
- Authors
Castilho de Arruda, Larissa Domingues; Giovanetti, Marta; Fonseca, Vagner; Zardin, Marina Castilhos Souza Umaki; Lichs, Gislene Garcia de Castro; Asato, Silvia; Esposito, Ana Olivia Pascoto; Tokeshi Müller, Miriam; Xavier, Joilson; Fritsch, Hegger; Lima, Mauricio; de Oliveira, Carla; Santos, Elaine Vieira; Maziero, Livia de Mello Almeida; Frias, Danila Fernanda Rodrigues; Ahad das Neves, Danielle; Ferreira da Silva, Liliane; Rodrigues Barretos, Ellen Caroline; Tsuha Oshiro, Paulo Eduardo; Modafari Goday, Bianca
- Abstract
Since its discovery in early 1916, dengue fever, a common vector-borne illness in Brazil, has resulted in extensive urban outbreaks and poses a serious threat to the public's health. Understanding the dynamics of Dengue Virus (DENV) serotypes circulating in different regions of Brazil is essential for implementing effective disease control and prevention measures. In response to this urgent need, we conducted an on-site training program in genomic surveillance in collaboration with the Central Laboratory of Health and the Secretary of Health of the Mato Grosso do Sul state. This initiative resulted in the generation of 177 DENV genome sequences collected between May 2021 and May 2022, a period during which over 11,391 dengue fever cases were reported in the state. Through this approach, we were able to identify the co-circulation of two different dengue serotypes (DENV1 and DENV2) as well as the existence of diverse viral lineages within each genotype, suggesting that multiple introduction events of different viral strains occurred in the region. By integrating epidemiological data, our findings unveiled temporal fluctuations in the relative abundance of different serotypes throughout various epidemic seasons, highlighting the complex and changing dynamics of DENV transmission throughout time. These findings demonstrate the value of ongoing surveillance activities in tracking viral transmission patterns, monitoring viral evolution, and informing public health actions.
- Subjects
MATO Grosso do Sul (Brazil); BRAZIL; DENGUE; GENOMICS; DENGUE viruses; VIRAL transmission; ARBOVIRUS diseases; PUBLIC health; PUBLIC health surveillance
- Publication
Viruses (1999-4915), 2023, Vol 15, Issue 9, p1790
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v15091790