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- Title
The Relationship between Thyroid Function and Depressive Symptoms--the FIN-D2D Population-Based Study.
- Authors
Saltevo, Juha; Kautiainen, Hannu; Mäntyselkä, Pekka; Jula, Antti; Keinänen-Kiukaanniemi, Sirkka; Korpi-Hyövälti, Eeva; Oksa, Heikki; Saaristo, Timo; Vanhala, Mauno
- Abstract
The association between thyroid function and depression is controversial. Both conditions express many similar symptoms, but the studies done give conflicting results. This study draws on a random, population-based sample of 4500 subjects aged 45-75 years old from Finland. The basic clinical study was done in 2007 for 1396 men and 1500 women (64% participation rate). Thyroid stimulating hormone (TSH), free thyroxine (F-T4), and free triiodothyronine (F-T3) were measured in 2013 from frozen samples. The 21-item Beck Depression Inventory (BDI-21) was applied to assess depressive symptoms (score ≥10 points). The prevalence of depressive symptoms was 17.5% in women and 12.5% in men. In women, the mean levels of TSH, F-T4, and F-T3 without depressive symptoms vs. with the presence of depressive symptoms were 1.92/1.97 mU/L, 13.1/13.1 pmol/L, and 3.91/3.87 pmol/L (NS), respectively. In men, the levels were 1.87/1.94 mU/L, 13.5/13.7 pmol/L, and 4.18/4.12 pmol/L (NS), respectively. In multiple regression analysis, TSH had no relationship to BDI-21 total score. We found no association between depressive symptoms and thyroid values.
- Subjects
FINLAND; HYPOTHYROIDISM diagnosis; THYROID disease diagnosis; THYROID gland physiology; SMOKING; ACADEMIC medical centers; ANALYSIS of covariance; ANTIDEPRESSANTS; ANTILIPEMIC agents; BLOOD pressure; BLOOD pressure measurement; C-reactive protein; CHOLESTEROL; DEMOGRAPHY; MENTAL depression; ALCOHOL drinking; ENDOCRINOLOGY; HIGH density lipoproteins; ANTIHYPERTENSIVE agents; HYPOTHYROIDISM; LOW density lipoproteins; POPULATION; SURVEYS; THYROID gland function tests; THYROTROPIN; THYROXINE; DATA analysis; PHYSICAL activity; WAIST circumference; DISEASE complications
- Publication
Clinical Medicine Insights: Endocrinology & Diabetes, 2015, Issue 8, p29
- ISSN
1179-5514
- Publication type
Article
- DOI
10.4137/CMED.S24111