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- Title
Cell cycle alterations in endometrial carcinoma.
- Authors
Bovicelli, Alessandro; D'Andrilli, Guiseppina; Giordano, Antonio
- Abstract
Endometrial carcinoma is the most common gynecological malignancy in Western countries and it is important to determine the genetic variants associated with disease since the genetic basis is poorly understood. Several molecular biological characteristics have been studied for their potential value in patient management. Deregulation of the control mechanisms of the cell cycle can initiate carcinogenesis, and play a role in progression to cancer. This review describes the current state of knowledge about the alterations of cell-cycle regulations in the context of p53 pathway, RB pathway, and p27 pathway in endometrial carcinoma.
- Subjects
ENDOMETRIAL cancer; CELL cycle; PATIENT management; TUMOR suppressor genes; UTERINE cancer; RETINOBLASTOMA
- Publication
Experimental Medicine, 2009, Vol 1, Issue 1, p3
- ISSN
1791-9967
- Publication type
Article