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- Title
Self-reported levels of education and disability progression in multiple sclerosis.
- Authors
D'hooghe, M. B.; Haentjens, P.; Van Remoortel, A.; De Keyser, J.; Nagels, G.
- Abstract
Objectives The purpose of our study is to investigate whether socioeconomic indicators such as education, financial concerns, employment, and living status are associated with disease progression in relapsing-onset and progressive-onset Multiple Sclerosis ( MS). Materials and methods We performed a cross-sectional survey among individuals with MS, registered by the Flemish MS society and included socioeconomic indicators. A Cox proportional hazard regression was performed with the time from MS onset and from birth to reach an ambulatory disability milestone corresponding to Expanded Disability Status Scale ( EDSS) 6 (requiring a cane) as outcome measure, adjusted for gender, age at MS onset, and immunomodulatory treatment. Results Among the participants with relapsing-onset MS, subjects reporting education for more than 12 years had a reduced risk of reaching EDSS 6 compared to subjects reporting education for less than 12 years [ HR from onset 0.68 (95% CI 0.49-0.95); HR from birth 0.71 (95% CI 0.51-0.99)]. In progressive-onset MS, longer education was associated with an increased hazard to reach EDSS 6 [ HR from onset 1.25 (95% CI 0.91-1.70); HR from birth 1.39 (95% CI 1.02-1.90)]. Conclusions Our study shows an association of self-reported levels of education with disability progression in MS, with the highest level being protective in relapsing-onset MS.
- Subjects
DISEASE progression; SOCIOECONOMIC factors; MULTIPLE sclerosis research; SELF-evaluation; DISABILITIES; HEALTH behavior
- Publication
Acta Neurologica Scandinavica, 2016, Vol 134, Issue 6, p414
- ISSN
0001-6314
- Publication type
Article
- DOI
10.1111/ane.12555