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- Title
AIDS and optic neuritis in a rhesus monkey infected with the R5 clade C SHIV-1157ipd3N4.
- Authors
García, Anapatricia; Siddappa, Nagadenahalli B.; Li, Qingsheng; Haase, Ashley T.; Paul, Katherine; Stroud, Fawn; Xiaodong Zhang; Fountain, Jack A.; Villinger, François; Novembre, Francis J.; Else, James G.; Evan Secor, W.; Ruprecht, Ruth M.
- Abstract
A Chinese rhesus macaque infected with the pathogenic CCR5-tropic clade C simian-human immunodeficiency virus, SHIV-1157ipd3N4, had persistent viremia, depletion of CD4+ T cells to <200 cells/μl, opportunistic infections, coagulopathy, and gradual development of bilateral blindness. MRI revealed marked thickening of both optic nerves. Histopathological evaluation showed diffuse cellular infiltration at necropsy and a focus of SHIV-infected cells. This is the first report of CNS pathology following chronic infection with an obligate R5 SHIV.
- Subjects
RHESUS monkeys; HIV; VIREMIA; BLOOD coagulation disorders; OPTIC nerve
- Publication
Journal of Medical Primatology, 2010, Vol 39, Issue 5, p356
- ISSN
0047-2565
- Publication type
Article
- DOI
10.1111/j.1600-0684.2010.00416.x