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- Title
Creating Diversity from Biomass: A Tandem Bio/Metal‐Catalysis towards Chemoselective Synthesis of Densely Substituted Furans.
- Authors
Ravasco, João M. J. M.; Monteiro, Carlos M.; Siopa, Filipa; Trindade, Alexandre F.; Oble, Julie; Poli, Giovanni; Simeonov, Svilen P.; Afonso, Carlos A. M.
- Abstract
A new chemoselective (enzymatic desymmetrization/Ru‐catalyzed C−H activation) sequence to obtain differently substituted furans from the largely available 2,5‐furandicarboxylic acid (FDCA) was developed. Series of di‐ and trisubstituted furans were prepared in very good yields and excellent chemoselectivity. This study discloses a new approach towards valorization of the furanics platform through the use of FDCA as a stable intermediate, thus circumventing the chemical instability of the parent 5‐hydroxymethylfurfural.
- Subjects
FURANS; BIOMASS; CHEMOSELECTIVITY; FURAN derivatives; RUTHENIUM catalysts; BIOCATALYSIS
- Publication
ChemSusChem, 2019, Vol 12, Issue 20, p4629
- ISSN
1864-5631
- Publication type
Article
- DOI
10.1002/cssc.201902051