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- Title
The clinical implications of serum ferritin in Kawasaki disease: a helpful biomarker for evaluating therapeutic responsiveness, coronary artery involvement and the tendency of macrophage activation syndrome.
- Authors
Zhen Qiu; Hui Hui Liu; Guo Zhen Fan; Wei Xia Chen; Peng Hu; Qiu, Zhen; Liu, Hui Hui; Fan, Guo Zhen; Chen, Wei Xia; Hu, Peng
- Abstract
<bold>Introduction: </bold>Serum ferritin (SF) is an acute-phase reactant in inflammatory diseases. Our aim was to analyze the clinical implications of SF in Kawasaki disease (KD).<bold>Methods: </bold>244 KD children were divided into 6 subgroups. SF, inflammatory mediators and blood cell counts were detected.<bold>Results: </bold>(1) SF dramatically increased in the acute phase of KD and maintained after IVIG therapy; (2) SF increased in IVIG-nonresponsive KD patients (AUC = 0.705; sensitivity: 57.10%; specificity: 82.90%); SF positively correlated with the internal diameter of the coronary artery (AUC = 0.603; sensitivity: 92.30%; specificity: 37.70%); (3) SF increased in 4 patients with the macrophage activation syndrome (MAS)/MAS tendency (979.03 ±474.19 μg/l).<bold>Conclusions: </bold>SF is implied to be a helpful biomarker for forecasting IVIG-nonresponsive KD, coronary artery abnormalities (CAAs) and MAS tendency.
- Subjects
MACROPHAGE activation syndrome; CORONARY arteries; MUCOCUTANEOUS lymph node syndrome; FERRITIN; BLOOD cell count; INTRAVENOUS immunoglobulins
- Publication
Archives of Medical Science, 2022, Vol 18, Issue 1, p267
- ISSN
1734-1922
- Publication type
journal article
- DOI
10.5114/aoms/144293