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- Title
Tackling metabolic defects in HFpEF.
- Authors
Wang, Rongling; Schiattarella, Gabriele G
- Abstract
This document provides an overview of the complex pathophysiology of heart failure with preserved ejection fraction (HFpEF) and the challenges in understanding and treating the condition. It emphasizes the role of obesity in HFpEF and the potential benefits of using glucagon-like peptide-1 receptor agonists (GLP-1RAs) in obese HFpEF patients. The concept of "energy resilience" is introduced to explain the metabolic changes in cardiometabolic HFpEF, and the potential role of reactive oxygen/nitrosative oxygen species (R/NOS) and microvascular dysfunction in HFpEF development is explored. The impact of hypoxia on cardiac metabolism and the potential effects of hypoxia-inducible factor 1-alpha (HIF1α) on metabolic remodeling in HFpEF are also discussed. The document concludes by suggesting that imbalances in energy substrates and metabolite-driven post-translational modifications (PTMs) may contribute to HFpEF and that targeting these PTMs could be a promising therapeutic approach. However, further research is needed to fully understand the underlying mechanisms of HFpEF and develop effective treatments.
- Subjects
HEART failure; NAD (Coenzyme); PYRUVATE dehydrogenase kinase; GLUCAGON-like peptide-1 receptor
- Publication
European Heart Journal, 2024, Vol 45, Issue 17, p1494
- ISSN
0195-668X
- Publication type
Article
- DOI
10.1093/eurheartj/ehad884