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- Title
Doxorubicin treatment inhibits PPARγ and may induce lipotoxicity by mimicking a type 2 diabetes-like condition in rodent models
- Authors
Arunachalam, Sankarganesh; Tirupathi Pichiah, P.B.; Achiraman, Shanmugam
- Abstract
Abstract: Doxorubicin-treated animals show elevated serum triglyceride and blood glucose levels. Adipocytes play an important role in buffering blood glucose and lipids. A raise in serum lipid level triggers adipogenesis in order to increase the lipid absorption capacity of adipose tissue. Doxorubicin inhibits adipogenesis through the down-regulation of PPARγ, a crucial component of the lipid metabolic pathway which controls the expression of glucose and fatty acid transporters. Doxorubicin-mediated down-regulation of PPARγ inhibits blood glucose and lipid clearance thereby causing hyperglycemia and hyperlipidemia resulting in lipotoxicity, glucotoxicity, inflammation and insulin resistance. Therefore we hypothesize that doxorubicin treatment could mimic a type 2 diabetic condition.
- Subjects
DOXORUBICIN; PEROXISOME proliferator-activated receptors; TYPE 2 diabetes; INSULIN resistance; LABORATORY rodents; BLOOD sugar; FAT cells
- Publication
FEBS Letters, 2013, Vol 587, Issue 2, p105
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2012.11.019