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- Title
RNA interference-mediated suppression of xanthine dehydrogenase reveals the role of purine metabolism in drought tolerance in Arabidopsis
- Authors
Watanabe, Shunsuke; Nakagawa, Ayami; Izumi, Shunsuke; Shimada, Hiroshi; Sakamoto, Atsushi
- Abstract
Abstract: We have previously demonstrated that RNA interference-mediated suppression of xanthine dehydrogenase (XDH), the rate-limiting enzyme in purine degradation, causes defects in the normal growth and development of Arabidopsis thaliana. Here, we investigated a possible role for XDH in drought tolerance, since this enzyme is also implicated in plant stress responses and acclimatization. When XDH-suppressed lines were subjected to drought stress, plant growth was markedly reduced in conjunction with significantly enhanced cell death and H2O2 accumulation. This drought-hypersensitive phenotype was reversed by pretreatment with exogenous uric acid, the catalytic product of XDH. These results suggest that fully functional purine metabolism plays a role in the Arabidopsis drought acclimatization.
- Subjects
DROUGHT tolerance; XANTHINE; DEHYDROGENASES; METABOLISM; BIODEGRADATION; ARABIDOPSIS thaliana; REACTIVE oxygen species; ACCLIMATIZATION (Plants)
- Publication
FEBS Letters, 2010, Vol 584, Issue 6, p1181
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2010.02.023