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- Title
The lipin protein family: Dual roles in lipid biosynthesis and gene expression
- Authors
Reue, Karen; Zhang, Peixiang
- Abstract
Abstract: The prevalence of obesity in the western world has focused attention on factors that influence triglyceride biosynthesis, storage, and utilization. Members of the lipin protein family have a newly discovered enzymatic role in triglyceride and phospholipid biosynthesis as a phosphatidate phosphatase, and also act as an inducible transcriptional coactivator in conjunction with peroxisome proliferator-activated receptor γ (PPARγ) coactivator-1α and PPARα. Through these activities, the founding member of the family, lipin-1, influences lipid metabolism and glucose homeostasis in diverse tissues including adipose tissue, skeletal muscle, and liver. The physiological roles of lipin-2 and lipin-3 are less well defined, but are likely to carry out similar functions in glycerolipid biosynthesis and gene expression in a distinct tissue distribution.
- Subjects
LIPIDS; PROTEINS; BIOSYNTHESIS; GENE expression
- Publication
FEBS Letters, 2008, Vol 582, Issue 1, p90
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2007.11.014