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- Title
Systemic mastocytosis with normal serum tryptase: rule or exception?
- Authors
Hermans, M.A.W.; Schreurs, M.W.J.; van Daele, P.L.A.
- Abstract
Systemic mastocytosis (SM) is a rare disease which is characterised by the accumulation of mast cells in >=1 extra-cutaneous organ, most often the bone marrow.[1] In the majority of patients, the activating D816V mutation in KIT induces increased proliferation and survival in the neoplastic mast cells. 2 † Bone marrow investigation was not always completely performed, as patients were often referred from other clinics after the diagnosis of mastocytosis was made. Further investigation should also be considered in patients with a tryptase level <=11.4 ng/mL with clinical symptoms that are suggestive of mastocytosis, especially adult-onset MPCM or Hymenoptera venom-related anaphylaxis.
- Subjects
MAST cell disease; TRYPTASE; SERUM
- Publication
Journal of the European Academy of Dermatology & Venereology, 2019, Vol 33, Issue 12, pe472
- ISSN
0926-9959
- Publication type
Article
- DOI
10.1111/jdv.15800