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- Title
Determining massage dose-response to improve cancer-related symptom cluster of pain, fatigue, and sleep disturbance: A 7-arm randomized trial in palliative cancer care.
- Authors
Miladinia, Mojtaba; Jahangiri, Mina; Kennedy, Ann Blair; Fagerström, Cecilia; Tuvesson, Hanna; Safavi, Shadi Sadat; Maniati, Mahmood; Javaherforooshzadeh, Fatemeh; Karimpourian, Hossein
- Abstract
Background: The efficacy of various massage doses in palliative cancer care settings is still debated, and no specific protocol is available. Aim: Evaluating response to various massage doses for symptom cluster of pain-fatigue-sleep. Design: A 7-arm randomized-controlled trial with weekly massage for 4 weeks depending on the prescribed dose (15-, 30-, or 60-min; 2× or 3×/week) and a 4-week follow-up. The intensities of pain, fatigue, and sleep disturbance were measured using a 0–10 scale at nine-timepoint; baseline, weekly during the intervention, and the follow-up period. Then, the mean scores of the three symptoms were calculated as the symptom cluster intensity at each timepoint. IRCT.ir IRCT20150302021307N5. Setting/participants: Adults with cancer (n = 273) who reported all three symptoms at three oncology centers in Iran. Results: The odds of clinical improvement (at least 30% reduction in symptom cluster intensity from baseline) increased with dose-escalation significantly [(OR = 17.37; 95% CI = 3.87–77.90 for 60-min doses); (OR = 11.71; 95% CI = 2.60–52.69, for 30-min doses); (OR = 4.36; 95% CI = 0.94–20.32, for 15-min doses)]. The effect durability was significantly shorter at 15-min doses compared to 30- and 60-min doses. The odds of improvement for doses 3×/week was not significant compared to doses 2×/week (OR = 12.27 vs OR = 8.34); however, the effect durability for doses 3×/week was significantly higher. Conclusions: The findings indicated that dose-escalation increases the efficacy of massage for the pain-fatigue-sleep symptom cluster. Although the 60-min doses were found to be more effective, the 30-min doses can be considered more practical because they are less costly and time-consuming. Our findings can be helpful to develop massage guidelines in palliative care settings. Trial registration: Iranian Registry of Clinical Trials, IRCT20150302021307N5.
- Subjects
IRAN; SLEEP disorders treatment; CANCER pain treatment; MASSAGE therapy; SPECIALTY hospitals; CONFIDENCE intervals; INTEGRATIVE medicine; RANDOMIZED controlled trials; CANCER patients; CANCER treatment; COMPARATIVE studies; HOLISTIC medicine; TREATMENT effectiveness; CANCER fatigue; RESEARCH funding; STATISTICAL sampling; ALTERNATIVE medicine; DOSE-response relationship in biochemistry; PALLIATIVE treatment; CANCER patient medical care
- Publication
Palliative Medicine, 2023, Vol 37, Issue 1, p108
- ISSN
0269-2163
- Publication type
Article
- DOI
10.1177/02692163221129158