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- Title
A novel oncogenic pathway by TLS-CHOP involving repression of MDA-7/IL-24 expression.
- Authors
Oikawa K; Tanaka M; Itoh S; Takanashi M; Ozaki T; Muragaki Y; Kuroda M; Oikawa, K; Tanaka, M; Itoh, S; Takanashi, M; Ozaki, T; Muragaki, Y; Kuroda, M
- Abstract
<bold>Background: </bold>Translocated in liposarcoma-CCAAT/enhancer binding protein homologous protein (TLS-CHOP) (also known as FUS-DDIT3) chimeric oncoprotein is found in the majority of human myxoid liposarcoma (MLS), but its molecular function remains unclear.<bold>Methods: </bold>We knockdowned TLS-CHOP expression in MLS-derived cell lines by a specific small interfering RNA, and analysed the gene expression profiles with microarray.<bold>Results: </bold>TLS-CHOP knockdown inhibited growth of MLS cells, and induced an anticancer cytokine, melanoma differentiation-associated gene 7 (MDA-7)/interleukin-24 (IL-24) expression. However, double knockdown of TLS-CHOP and MDA-7/IL-24 did not inhibit MLS cell growth.<bold>Conclusion: </bold>Repression of MDA-7/IL-24 expression by TLS-CHOP is required for MLS tumour growth, and TLS-CHOP may become a promising therapeutic target for MLS treatment.
- Publication
British Journal of Cancer, 2012, Vol 106, Issue 12, p1976
- ISSN
0007-0920
- Publication type
journal article
- DOI
10.1038/bjc.2012.199