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- Title
Bismuth-Based Therapy: The New Therapy for Obese Patients Undergoing Gastric Bypass Surgery?
- Authors
Maria, Cerqueira Rute; Rodriguez, Correia Manuel; Ines, Pita; Helder, Vilar; Mafalda, Sousa; Ricardo, Veloso; Conceição, Manso M.
- Abstract
Aims: Our aim was to assess, in obese patients undergoing Roux-en Y gastric bypass surgery, the bismuth quadruple therapy (BQT) eradication rates at the first-line Helicobacter pylori (Hp) treatment as proposed by the Maastricht V/Florence consensus in areas with high clarithromycin (CLT) resistance rates–10 days proton pump inhibitor bid and three-in-one single capsule bismuth therapy containing bismuth, metronidazole, and tetracycline, marketed as Pylera four times a day. Methods: This is a single-center prospective study over a 3-year period. Endoscopy and Hp assessment by histology was performed at baseline, and posttreatment Hp status was assessed by C13 urea breath test 4–6 weeks after the end of therapy. Data analysis was performed using the IBM® SPSS® Statistics 28.0 (IBM Corp. 2021, Armonk, NY) using mostly nonparametric comparisons (α = 0.05). Results: The study cohort consisted of 598 adult obese Hp-positive patients [476, 78.6% female, age 43.2 (± 10.4) years] consecutively scheduled for Hp eradication therapy. Hp was eradicated in 500 patients [83.6.3% (95% CI: 80.4%–86.5%)], and the eradication was independent of gender, age, endoscopic diagnosis, and smoking status (p > 0.05). Conclusion: Ten days of BQT did achieve Maastricht V/Florence recommended first-line eradication rates (at least 80%) in obese Portuguese patients undergoing Roux-en Y gastric bypass, being by now the most reliable choice for Hp eradication.
- Subjects
NEW York (N.Y.); GASTRIC bypass; INTERNATIONAL Business Machines Corp.; OBESITY; PROTON pump inhibitors; HELICOBACTER pylori infections; PORTUGUESE people; HELICOBACTER pylori
- Publication
Obesity Surgery, 2024, Vol 34, Issue 1, p123
- ISSN
0960-8923
- Publication type
Article
- DOI
10.1007/s11695-023-06549-8