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- Title
Reply: Follow the allosteric transitions to predict variant pathogenicity: a channel-specific approach.
- Authors
Montanucci, Ludovica; Brünger, Tobias; Lal, Dennis
- Abstract
The article is a response to a comment on a previous study about predicting the pathogenicity of variants in ion channels. The authors of the response acknowledge that their cross-channel approach may not be accurate for all families of ion channels due to their structural and functional differences. They suggest that a protein-specific approach, tailored to the structure and activation mechanism of each ion channel, may be more effective. The response highlights the merits of this approach, including the need for clinical-grade accuracy, consideration of protein dynamics, and the refinement of predictive features. The study by Absalom et al. demonstrates the potential of a protein-specific approach to improve variant classification and deepen our understanding of biological functions.
- Subjects
PROTEIN structure prediction; ION channels
- Publication
Brain: A Journal of Neurology, 2024, Vol 147, Issue 5, pe41
- ISSN
0006-8950
- Publication type
Article
- DOI
10.1093/brain/awae009