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- Title
Phytochemical analysis, antibacterial, and antifungal assessment of aerial parts of Polygonatumverticillatum.
- Authors
Khan, Haroon; Saeed, Muhammad; Muhammad, Naveed; Perviz, Samreen
- Abstract
The current study was designed to assess the phytochemical profile, antibacterial, and antifungal activities of the crude methanol extract of the aerial parts of Polygonatum verticillatum (PA) and its various subsequent solvent fractions using agar well diffusion, agar tube dilution, and microdilution methods. Phytochemical analysis showed positive for different chemical groups and also contained marked quantity of saponin and flavonoid contents. Significant antibacterial activity was observed against various tested pathogenic bacteria. The only susceptible Gram-positive bacterium was Bacillussubtilis and their minimum inhibitory concentrations (MICs) measured ranged from 11–50 µg/ml. The sensitive Gram-negative bacteria were Salmonella typhi and Shigellaflexeneri. The estimated MICs were in the range of 2–7 µg/ml and 8–50 µg/ml for S. typhi and S. flexeneri, respectively. However, the antifungal activity of the plant was limited to Microsporum canis and their MICs ranged from 60 to 250 µg/ml. Our study confirmed significant antibacterial potential of the plant and substantiated its folk use in dysentery and pyrexia of multiple origins.
- Subjects
PHYTOCHEMICALS; ANTIBACTERIAL agents; ANTIFUNGAL agents; METHANOL; SOLOMON'S seal
- Publication
Toxicology & Industrial Health, 2016, Vol 32, Issue 5, p841
- ISSN
0748-2337
- Publication type
Article
- DOI
10.1177/0748233713512362