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- Title
Effect of HIV Infection Status and Anti-Retroviral Treatment on Quantitative and Qualitative Antibody Responses to Pneumococcal Conjugate Vaccine in Infants.
- Authors
Madhi, Shabir A.; Adrian, Peter; Cotton, Mark F.; Mcintyre, James A.; Jean-Philippe, Patrick; Meadows, Shawn; Nachman, Sharon; Käyhty, Helena; Klugman, Keith P.; Violari, Avye
- Abstract
Serotype-specific antibody concentration and opsonophagocytic activity (OPA) were evaluated after 3 doses of pneumococcal conjugate vaccine. Groups included human immunodeficiency virus (HIV)-positive infants with CD4+ cell percentages ⩾ 25% who initiated immediate antiretroviral treatment (the HIV+/ART+ group) or whose antiretroviral treatment was deferred until clinically or immunologically indicated (the HIV+/ART- group). Immune responses were also evaluated in HIV-noninfected infants born to HW-seronegative (M-/I-) or HW-positive mothers (M+/I-). Antibody concentrations were similar between HIV+/ART+ and HW+I ART- infants. However, antibody concentrations were lower in M-/I- infants than in M+/I- infants. Nevertheless, M-/ I - infants had superior OPA responses, compared with those in HIV+/ART+ infants, who in turn had better OPA responses, compared with those in HIV+/ART- infants.
- Subjects
HIV infections; RETROVIRUS disease treatment; VACCINATION of infants; PNEUMOCOCCAL vaccines; SEROTYPES; ANTIBODY-drug conjugates; NEWBORN infant immunology; IMMUNOLOGICAL deficiency syndromes; IMMUNE response
- Publication
Journal of Infectious Diseases, 2010, Vol 202, Issue 3, p355
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/653704