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- Title
Small cell lung cancer presenting as a solitary pulmonary nodule.
- Authors
Quoix, Elisabeth; Fraser, Richard; Wolkove, Norman; Finkelstein, Harriet; Kreisman, Harvey; Quoix, E; Fraser, R; Wolkove, N; Finkelstein, H; Kreisman, H
- Abstract
Small cell lung cancer (SCLC) rarely presents radiographically as a solitary pulmonary nodule (SPN). Twenty-five patients with this feature were identified among 408 individuals with SCLC at McGill University (Montreal, Quebec) from 1979 through 1984. Of these, 15 (60%) were confirmed on pathologic review as SCLC (ten intermediate cell, four oat cell, one indeterminate). Pathologic review of a control group comprising 24 other limited-disease patients who were long-term survivors (greater than 20 months) confirmed 20 (84%) as SCLC (eight intermediate cell, 12 oat cell). Ten of the 15 patients with SPN were resected whereas five had chemotherapy and/or radiotherapy as primary treatment. Postoperative chemotherapy was administered to most of the resected patients. The median survival of the 15 patients with SPN was 24 months, a significantly longer survival than the other patients with SCLC. This improved prognosis in patients with SPN may be due to smaller initial tumor burden or to a fundamental biologic difference between SPN and other forms of SCLC.
- Publication
Cancer (0008543X), 1990, Vol 66, Issue 3, p577
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19900801)66:3<577::AID-CNCR2820660328>3.0.CO;2-Y