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- Title
Tumor Necrosis Factor-α-Converting Enzyme: Its Role in Community-Acquired Pneumonia.
- Authors
Greene, Catherine; Lowe, Gregory; Taggart, Clifford; Gallagher, Paula; McElvaney, Noel; O'Neill, Shane
- Abstract
Bronchoalveolar lavage fluid recovered from infected and uninvolved lungs of patients with community-acquired pneumonia (CAP; n = 16) on day 6 ± 0.8 was analyzed for cytokine, soluble receptor, and antagonist levels. The role of tumor necrosis factor (TNF)-α-converting enzyme (TACE) in the resolution of the local inflammatory response was investigated. TNFα, interleukin (IL)-1β, and IL-6 were elevated in the infected versus uninvolved lobe, whereas IL-10 was not. Epithelial lining fluid (ELF) cytokine levels correlated with intracellular cytokine expression. Levels of proTNF-α were reciprocally related to TNF-α ELF levels. Levels of soluble receptors, generated by TACE cleavage of membrane-bound precursors, were compartmentalized to infected ELF. TACE was down-regulated by internalization in cells from the site of infection. These data demonstrate that, in vivo during CAP, TACE has a role in regulating resolution of the local inflammatory response by modulating levels of pro- and counterinflammatory mediators.
- Subjects
BRONCHOALVEOLAR lavage; PNEUMONIA; TUMOR necrosis factors
- Publication
Journal of Infectious Diseases, 2002, Vol 186, Issue 12, p1790
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/345799