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- Title
Exposure of hepatitis C virus-negative recipients to > or =2 infected blood donors.
- Authors
Laskus, Tomasz; Wilkinson, Jeffrey; Rakela, Jorge; Wang, Lian-Fu; Radkowski, Marek; Nowicki, Marek; Laskus, T; Wang, L F; Radkowski, M; Nowicki, M; Wilkinson, J; Rakela, J
- Abstract
This study analyzed 4 cases of hepatitis C virus (HCV)-naive transfusion recipients who developed hepatitis after receiving blood from >1 HCV-infected donor. One recipient was exposed to 4 donors, 2 were exposed to 3 donors, and 1 was exposed to 2 donors. For 3 recipients, the strain from 1 of the donors predominated in all follow-up samples collected for 8-40 months. For 2 recipients, the strain from the second donor was occasionally detectable with sensitive strain-specific assays. For the fourth recipient, the initially dominant strain was later supplanted by a strain from the other donor. Simultaneous exposure to multiple HCV strains may result in concomitant infection by >1 strain, although a single strain rapidly establishes its dominance. These observations are compatible with the presence of competition among infecting HCV strains that results in the dominance of 1 strain and competitive exclusion or suppression of other strains.
- Subjects
HEPATITIS C virus; BLOOD transfusion reaction; REVERSE transcriptase; PATIENTS; RNA analysis; HEPATITIS C transmission; PROTEINS; REVERSE transcriptase polymerase chain reaction; SEQUENCE analysis; HEPATITIS C; HEPATITIS viruses; NUCLEOTIDES; DOCUMENTATION; GENOTYPES; IMMUNITY; POLYMERASE chain reaction; DISEASE complications
- Publication
Journal of Infectious Diseases, 2001, Vol 183, Issue 4, p666
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1086/318531