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- Title
Prenatal Exposures to Perfluorinated Chemicals and Anthropometric Measures in Infancy.
- Authors
Andersen, Camilla Schou; Fei, Chunyuan; Gamborg, Michael; Nohr, Ellen Aagaard; Sørensen, Thorkild I. A.; Olsen, Jørn
- Abstract
Perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) are persistent chemicals that may affect growth early in life. The authors estimated the associations between maternal plasma levels of PFOS and PFOA and infants’ weight, length, and body mass index development during the first year of life. Fourteen hundred women were randomly selected from the Danish National Birth Cohort among those who provided blood samples early in pregnancy and gave birth to liveborn singletons between 1996 and 2002. Weight and length information at 5 and 12 months of age was available for 1,010 children. Multiple linear regression models were used for analyses, and maternal PFOS and PFOA concentrations (ng/mL) were inversely related to children's weight in the first year of life: adjusted regression coefficients: −1.1 g (95% confidence interval (CI): −4.6, 2.3) at 5 months and −5.8 g (95% CI: −10.4, −1.2) at 12 months for PFOS; −10.6 g (95% CI: −30.2, 8.9) at 5 months and −19.7 g (95% CI: −45.9, 6.5) at 12 months for PFOA. A similar pattern was observed for body mass index measurements, and no associations with length were found. After sex stratification, the inverse associations with weight and body mass index were more pronounced in boys, and no clear association was seen for girls.
- Subjects
DENMARK; ANALYSIS of variance; ANTHROPOMETRY; BLOOD testing; BODY weight; CONFIDENCE intervals; STATISTICAL correlation; FLUOROCARBONS; INFANT development; LONGITUDINAL method; MATERNAL-fetal exchange; SEX distribution; STATURE; ENVIRONMENTAL exposure; MULTIPLE regression analysis; BODY mass index; BLOOD; CHILDREN
- Publication
American Journal of Epidemiology, 2010, Vol 172, Issue 11, p1230
- ISSN
0002-9262
- Publication type
Article
- DOI
10.1093/aje/kwq289