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- Title
Systematic analysis of copper, zinc, and selenium levels in JAK2 V617F-positive myeloproliferative neoplasms.
- Authors
Shivarov, Velizar; Tsvetkova, Gergana; Atanasova, Bisera; Genova, Mariana P.; Ivanova, Irena; Hadjiev, Evgueniy; Ivanova, Milena
- Abstract
This document is a letter published in the Annals of Hematology. The authors conducted a systematic analysis of copper, zinc, and selenium levels in patients with JAK2 V617F-positive myeloproliferative neoplasms (MPNs). They found that the presence of the JAK2 V617F mutation was associated with higher copper and zinc levels but lower selenium levels. Additionally, they observed that copper levels were higher in essential thrombocythemia (ET) and polycythemia vera (PV) patients, while zinc levels were higher in all three MPN entities. However, selenium levels were lower in all three entities compared to healthy controls. The authors suggest that these findings provide testable hypotheses for the role of copper, zinc, and selenium in MPNs and raise questions about the potential clinical justification for nutritional supplementation with these elements in JAK2 V617F-positive MPNs.
- Subjects
MYELOPROLIFERATIVE neoplasms; COPPER analysis; SELENIUM; MYELOFIBROSIS; ZINC; COPPER
- Publication
Annals of Hematology, 2024, Vol 103, Issue 6, p2177
- ISSN
0939-5555
- Publication type
Article
- DOI
10.1007/s00277-024-05624-z