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- Title
N-methyl-D-aspartate receptor antibodies in pediatric dyskinetic encephalitis lethargica.
- Authors
Dale RC; Irani SR; Brilot F; Pillai S; Webster R; Gill D; Lang B; Vincent A; Dale, Russell C; Irani, Sarosh R; Brilot, Fabienne; Pillai, Sekhar; Webster, Richard; Gill, Deepak; Lang, Bethan; Vincent, Angela
- Abstract
Encephalitis lethargica (EL) describes an encephalitis with psychiatric, sleep, and extrapyramidal movement disorders. Dyskinetic and parkinsonian forms have been described. EL shares clinical features with the anti-N-methyl-D-aspartate receptor (NMDAR-Ab) encephalitis. We studied 20 sera from pediatric patients with contemporary EL. Ten sera (from 2 males and 8 females, aged 1.3-13 years) and 6/6 cerebrospinal fluid samples were positive for NMDAR-Ab. NMDAR-Ab-positive patients had dyskinesias, agitation, seizures, and insomnia, whereas parkinsonism and somnolence dominated in the NMDAR-Ab-negative children. We were unable to identify any tumors. The dyskinetic form of EL is an NMDAR-Ab encephalitis and can affect very young children.
- Publication
Annals of Neurology, 2009, Vol 66, Issue 5, p704
- ISSN
0364-5134
- Publication type
journal article
- DOI
10.1002/ana.21807