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- Title
PRNP Val129 homozygosity increases risk for early-onset Alzheimer's disease.
- Authors
Bart Dermaut; Esther A. Croes; Rosa Rademakers; Marleen Van Den Broeck; Marc Cruts; Albert Hofman; Cornelia M. Van Duijn; Christine Van Broeckhoven
- Abstract
We analyzed the PRNP M129V polymorphism in a Dutch population-based early-onset Alzheimer's disease sample. We observed a significant association between early-onset Alzheimer's disease and homozygosity of M129V (odds ratio [OR], 1.9; 95% confidence interval [CI], 1.13.3; p = 0.02) with the highest risk for V homozygotes (OR, 3.2; 95% CI, 1.47.1; p < 0.01). In patients with a positive family history, these risks increased to 2.6 (95% CI, 1.35.3; p < 0.01) and 3.5 (95% CI, 1.39.3; p = 0.01), respectively. Ann Neurol 2003;53;409412
- Publication
Annals of Neurology, 2003, Vol 53, Issue 3, p409
- ISSN
0364-5134
- Publication type
Article