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- Title
Decreased cerebrospinal fluid levels of β-phenylethylamine in patients with Rett syndrome.
- Authors
Satoi, Mika; Matsuishi, Toyojiro; Yamada, Shigeto; Yamashita, Yushiro; Ohtaki, Etsuo; Mori, Kenji; Riikonen, Raili; Kato, Hirohisa; Percy, Alan K.
- Abstract
To clarify the mechanism of brain impairment in Rett syndrome, we measured the cerebrospinal fluid levels of β-phenylethylamine (PEA) in 17 patients with Rett syndrome. Findings were compared with those obtained in age-matched controls and diseased controls. The cerebrospinal fluid level of PEA was significantly lower in patients with Rett syndrome than in the controls (31% of control values). The alteration in the cerebrospinal fluid level of PEA may reflect dopamine system impairment in Rett syndrome. Ann Neurol 2000;47:801-803
- Publication
Annals of Neurology, 2000, Vol 47, Issue 6, p801
- ISSN
0364-5134
- Publication type
Article
- DOI
10.1002/1531-8249(200006)47:6<801::AID-ANA13>3.0.CO;2-L