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- Title
Association of early-onset Alzheimer's disease with an interleukin-1α gene polymorphism.
- Authors
Grimaldi, Luigi M. E.; Casadei, Valeria M.; Ferri, Cinzia; Veglia, Fabrizio; Licastro, Federico; Annoni, Giorgio; Biunno, Ida; De Bellis, Gianluca; Sorbi, Sandro; Mariani, Claudio; Canal, Nicola; Griffin, W. Sue T.; Franceschi, Massimo
- Abstract
Overexpression of the pluripotent cytokine interleukin-1 (IL-1) by microglial cells correlates with formation of neuritic β-amyloid plaques in Alzheimer's disease (AD). We evaluated polymorphisms in the genes coding for the IL-1α, IL-1β, and IL-1 receptor antagonist cytokines, and tested their association with the occurrence and age at onset of sporadic AD. We found a strong association between the IL-1A T/T genotype and AD onset before 65 years of age (odds ratio, 4.86), with carriers of this genotype showing an onset of disease 9 years earlier than IL-1A C/C carriers. A weaker association with the age at onset was also shown for the IL-1B and IL-1RN genes. These data suggest either a direct effect of the IL-1 gene family, mainly IL-1A, on the clinical onset of AD, or a linkage dysequilibrium with an unknown locus relevant to AD on chromosome 2. Ann Neurol 2000;47:361-365
- Publication
Annals of Neurology, 2000, Vol 47, Issue 3, p361
- ISSN
0364-5134
- Publication type
Article
- DOI
10.1002/1531-8249(200003)47:3<361::AID-ANA12>3.0.CO;2-N