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- Title
De Novo Lipogenesis Products and Endogenous Lipokines.
- Authors
Yilmaz, Mustafa; Claiborn, Kathryn C.; Hotamisligil, Gökhan S.
- Abstract
Recent studies have shown that in addition to their traditionally recognized functions as building blocks, energy stores, or hazardous intermediates, lipids also have the ability to act as signaling molecules with potent effects on systemic metabolism and metabolic diseases. This Perspective highlights this somewhat less apparent biology of lipids, especially focusing on de novo lipogenesis as a process that gives rise to key messenger molecules mediating interorgan communication. Elucidating the mechanisms of lipid-dependent coordination of metabolism promises invaluable insights into the understanding of metabolic diseases and may contribute to the development of a new generation of preventative and therapeutic approaches.
- Subjects
LIPID synthesis; METABOLISM; METABOLIC disorders; CIRCULATING anticoagulants; PHYSIOLOGICAL effects of lipids; ADIPOSE tissues; ANIMALS; CELLULAR signal transduction; FATTY acids; GENETIC disorders; LIPID metabolism disorders; LIVER
- Publication
Diabetes, 2016, Vol 65, Issue 7, p1800
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/db16-0251